NbMoTaWZr-HfC composite is composed of high temperature strengthened particles and refractory high entropy alloy. It is difficult to prepare the spherical powder by traditional gas atomization due to its high melting point characteristics. In this work, NbMoTaWZr-HfC spherical powder is successfully synthesized by spray granulation combined with radio frequency plasma spheroidization. The macroscopic properties, phase composition and microstructure of the powder are studied and analyzed. Results reveal that the shape of the composite powder is spherical and the particle size is range from 13.31 to 32.11 μm, D50=19.62 μm. The sphericity, flow rate and bulk density of the spheroidized powder are 0.98、8.9 s/50g，7.20 g/cm3, respectively. Moreover, the main phases of NbMoTaWZr-HfC spherical powder are body-centered-cubic ( BCC )+ ZrO2 + HfC phase and it has dendritic and cellular structure.The elements distribution in the spherical NbMoTaWZr-HfC powder is uniform, while elemental segregation at the dendritic scale region, high melting point elements such as W, Mo, Ta are enriched in the dendrite arm, and low melting point elements such as Nb, Zr are enriched at the interdendritic region, and the Hf are uniformly distributed,