The finite element method was adopted to analyze the temperature state of titanium alloy seamless pipe during the multi-stand continuous rolling. The simulation results show that with increasing the rolling passes, the outer surface temperature under the groove vertex is decreased at a gradually reducing rate, the center temperature is basically increased at a gradually reducing rate, and the outer surface temperature under the groove taper is continuously increased. The circumferential unevenness of center temperature is decreased in odd passes and increased in even passes. However, the unevenness of temperature distribution on the outer surface has opposite variation trend. The rolling reduction of the front pass shows a negative correlation with temperature rise at the groove taper of the next pass. In addition, decreasing the rolling reduction of the former pass can significantly improve the circumferential temperature unevenness of the next pass. The results of temperature measurement and grain morphology show that the simulation results are in good agreement with the experiment results.