ZrAl alloy is a potential space material for aerospace. Zr-6Al-0.1B alloy was prepared by vacuum hot pressing sintering. The isothermal compression tests of hot-pressed sintered Zr-6Al-0.1B alloy were carried out under the conditions of deformation temperature 950 ℃ ~ 1150 ℃ and strain rate 0.01 s-1 ~ 1 s-1 using Gleeble-3500 thermal simulation machine. The results show that at the beginning of deformation, the stress increases rapidly with the increase of strain and reaches the peak quickly. Then, the stress decreases continuously with the increase of strain, and there is no stress equilibrium stage. With the decrease of the deformation temperature or the increase of the strain rate, the stress-strain curve shifts to the high stress region, indicating that the hot-pressed sintered Zr-6Al-0.1B alloy is a sensitive material for deformation temperature and strain rate. The Johnson-Cook constitutive model of hot-pressed sintered Zr-6Al-0.1B alloy was established, the temperature sensitivity coefficient D and strain rate sensitivity coefficient C were modified. Through qualitative and quantitative comparative analysis between the predicted value by the model and the tested value, indicating the model has higher prediction accuracy when C is modified alone. This study can provide guidance for the selection of subsequent hot working parameters of hot-pressed sintered Zr-6Al-0.1B alloy, and provide a reliable constitutive model for the corresponding numerical simulation research.