The constant strain rate compression experiments were conducted on Mo-14Re alloy by the Gleeble-3500 thermal simulation testing machine, the high-temperature were selected at 1400℃, 1500℃, 1600℃, and strain rates of 0.01 s_-1^{, 0.1 s}_-1^{, 1 s}_-1^{, and 10 s_-1}.During the hot deformation process, the flow stress decreases with the increase of deformation temperature and the decrease of strain rate, which is due to the relative effect of work hardening and dynamic softening under different conditions. Based on the Arrhenius model and Zener Hollomon function, a constitutive equation for the flow stress of Mo-14Re alloy was established, and the activation energy for hot deformation of Mo-14Re alloy was obtained to be 588.31 kJ . mol-1. According to the established Hot processing map, the reasonable forming process parameters of Mo-14Re alloy are that the temperature is 1400℃~1600℃, the strain rate is 0.0089~0.14s_-1^{, and the power dissipation coefficient} Not less than 0.22, which is a reasonable process parameter for Mo-14Re alloy.