The electrochemical corrosion, wear, and tribocorrosion behavior of the novel Ti-19Zr-10Nb-1Fe alloy were investigated. The electrochemical corrosion analysis results show that the corrosion resistance of the Ti-19Zr-10Nb-1Fe alloy is better than that of the Ti-6Al-4V alloy under the test conditions in this research. Compared with the static electrochemical corrosion, the corrosion resistance of Ti-19Zr-10Nb-1Fe alloy during tribocorrosion decreases significantly, because the wear accelerates corrosion. The wear volume of Ti-19Zr-10Nb-1Fe alloy is increased with the increase in applied load whether the electrochemical corrosion occurs or not. Due to the acceleration effect of electrochemical corrosion, the wear volume caused by electrochemical corrosion is larger than that without electrochemical corrosion. The results of W_a/W_c are much greater than 10, indicating that during the tribocorrosion process, the material loss caused by mechanical wear is much larger than that caused by electrochemical corrosion. Through SEM observation of the wear morphologies of Ti-19Zr-10Nb-1Fe alloy after tribocorrosion, it can be inferred that the micro-abrasion is the main wear mechanism. The above results show that during the tribocorrosion process, the corrosion accelerates wear, and the wear accelerates corrosion.