The wide compositional space of multi-component Zr-based metallic glass gives rise to a huge challenge for the discovery of the Zr-based alloys with excellent glass-forming ability. Moreover, most of the bulk-sized Zr-based metallic glasses contain either the toxic element Be or precious metals. Thus, economical approaches using to search multi-component bulk-sized Zr-based metallic glass free of poisonous and noble elements are extremely necessary. Here, a new Zr₅₀Ti₅Cu₂₇Ni₁₀Al₈ metallic glass, with a critical diameter of 10 mm, was explored after only a few experimental trials through the method of proportional mixing of the binary eutectics and slightly partial replacing of element. The thermal stability and the hardness of this metallic glass were also respectively investigated by in-situ high-temperature X-ray diffraction and nanoindentation experiments.