TA15 titanium alloy is a new key titanium alloy for the carrier-based aircraft in China. Under the hot salt corrosion stress, the high temperature performance has a critical effect on the service performance and service life of key structural components in the aircraft. In order to deeply analyze the influence of hot salt stress corrosion on the high-temperature properties of TA15 titanium alloy and the mechanism of hot salt stress corrosion of TA15 titanium alloy, the typical large TA15 titanium alloy bar with φ 400mm was taken as the study object in this paper, and surface treatment of materials was carried out under different corrosion conditions. The stress-rupture properties were tested at high temperature stress loads of 500℃ under 470MPa. Then, SEM, EDS and EBSD methods were adopted to characterize the micro-structure of the samples before and after the loading. The results have shown that the hot salt stress corrosion of the alloy is very sensitive at 500℃and 470MPa. Hot salt stress corrosion has complex chemical reaction along the α phase boundary (β matrix), forming corrosion oxide and expanding inwards. Due to the force, the propagation of corrosion crack is accelerated, which leads to forming the feature of the inter-granular fracture and reduces the durability life.