Powder metallurgy is an effective way to produce low-cost and high-performance titanium and titanium alloys. The as-sintered Ti-6Al-4V ingots produced by hydrogenated dehydrogenation, cold isostatic pressing and vacuum pressure-less sintering have low interstitials content (O<0.16 wt.%, N<0.05 wt.%, H<0.015 wt.%), near-equiaxed ? microstructure, better mechanical properties (UTS>930 MPa, YS>870 MPa, El>14%). The results also show that HDH process can obtain very low interstitials content titanium powder. The increase of interstitials concentration is mainly due to the operation, transfer and storage of powder and powder compact. Benefit from fine grain and near-net-shape characteristics of powder metallurgy titanium alloy, as-sintered ingots can be directly used to prepare final titanium alloy products without cogging down. Then, the near shape PM Ti can increase materials utilization rate, reduce deformation during hot working. So, the as-sintered PM Ti instead of as-forged Ti can significantly reduce the cost of titanium products.