A series of carbon supports with different surface chemical nature were obtained by supersonic-treatment on active carbon under various conditions, and characterized by BET and acid-base titration. The supersonic-treatment carbon supported Pt/C catalysts were prepared and the effect of the supersonic-treatment of active carbon on its activities was investigated with application in catalytic reaction. The results revealed that the contents of surface impurities, the value of pH and the mesoporous capacity had biggish change after supersonic treatment. Pt/C catalyst employed the 60 min supersonic-treatment active carbon supports with bigger mesoporous capacity showed the highest catalytic activity of hydrogenation reaction. Based on these results above, we discussed effect of supersonic-treatment for active carbon supports on activity of Pt/C catalysts.