The effects of heat treatment parameters on the microstructure and mechanical properties of Ti-6 Cr-5 V-5 Mo-4 Al-1 Nb( Ti-65541) alloy were investigated,such as solution temperature,aging temperature and time. The results indicate that the fine secondary α phase precipitates in the matrix,while the primary α phase disappears completely after solution above the β phase transition temperature and aging. However,the secondary α phase and primary α phase exist simultaneously after solid solution at lower temperature and aging. Besides,the aging temperature has the most significant influence on its strength and plasticity,followed by solution temperature,and the aging time has the weakest effect. With the increase of aging temperature,the tensile strength and yield strength of Ti-65541 alloy decrease,and the plasticity increases. As the solution temperature increases,the strength increases and plasticity decreases. While with the extension of aging time,the strength and plasticity of Ti-65541 alloy generally decrease. The perfect comprehensive performance can be obtained after solution in the temperature range of 740 ～ 760 ℃ and aging treatment in the temperature range of 540 ～ 580 ℃ with 4 ～ 6 h.