The effects of heat treatment on the microstructure,tensile property,impact toughness of the hot rolled Ti-5331 alloy plate,which used for the nuclear reactor shells were investigated. The results show that the content of primary α phase decreases and the content of β phase increases with the increase of the annealing temperature below the phase transition point of Ti-5331 alloy. Annealing at 700 ℃,the static recrystallization begins to occur. The microstructure shows the equiaxed and the duplex feature after 800 ℃ and 900 ℃ annealing,respectively. Above 950 ℃ annealing,it shows the widmanstatten microstructure. With the increase of the annealing temperature,the fracture strength of the alloy plate first decreases and then increases,the yield strength and the yield ratio both gradually decreases. Additionally,the impact toughness of the alloy plate first increases and then decreases with the increasing of the annealing temperature,and the annealing temperature has little influence on the plasticity of the Ti-5331 alloy plate. At 900 ℃ × 1 h/AC annealing,Ti-5331 alloy plate has the excellent comprehensive performance,for the tensile strength is about 920 MPa,the elongation is 15%,and V-notch impact toughness can reach 93 J/cm2.