In this paper,the orthogonal experiment method and spark plasma sintering(SPS)technology were used to produce Ti-6Al-4V+x Y_2O_3 alloy,and the factors which affect the microstructure,density and mechanical properties of Ti-6Al-4V alloy,such as sintering temperature,sintering pressure,Y2O3content and soaking time were investigated.The results indicate that the degree of influence on density in turns are sintering temperature,sintering pressure,Y2O3content and soaking time.While for the mechanical properties,the orders are sintering temperature,Y_2O_3 content,sintering pressure and soaking time.When the sintering temperature is 1 200℃,pressure is 50 MPa,soaking time is 5 min,and Y_2O_3 content is 0.6%,the density and compressive strength of sintered samples can reach 4.413 8 g/cm3 and1 881.4 MPa respectively,which is much better than others.The compressive strength increases by 15.7%compared to the unadded Y2O3.