Through finite element simulation of the drawing process of TC4 alloy, multi-pass drawing experiments were conducted using optimized process parameters. The microstructure and texture of the TC4 alloy wire were tested, as well as the yield strength and tensile strength under different strain levels in a single pass. The results indicate that the optimal drawing process parameters for TC4 alloy wire were determined through finite element simulation analysis combined with actual production. Analysis of the TC4 alloy structure before and after drawing shows that the larger the total deformation, the easier the spheroidization of β grains occurs, and the structure becomes more uniform, with the texture strength increasing from 9.17 to 11.43. As the strain decreases, the elongation of the alloy drops to 14.1%, and the tensile strength of the drawn alloy increases, reaching a maximum of 1095 MPa. This demonstrates that the finite element simulation results provide reliable references for the experiments.